SYNTHESIS AND BIOLOGICAL EVALUATION OF SPIRO (INDOLE-THIAZOLIDINE) DERIVATIVES AS ANTIMICROBIAL AGENTS
作者: PRIYANKA NIVRUTTI SHINDEMANISH ASHOK RASKAR
作者单位: 1Department of Pharmaceutical Chemistry, Dr Vithalrao Vikhe Patil Foundation’s College of Pharmacy, Vilad Ghat; M. I.D. C, Ahmednagar 414111, Maharashtra, India. priyankashindep13@gmail.com
刊名: International Journal of Current Pharmaceutical Research, 2019, pp.71-74
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijcpr.2019v11i6.36346
原始语种摘要: Objective: The present study aims to synthesize and biological evaluation of Spiro-[Indole-Thiazolidine] derivatives as antimicrobial agents. Methods: The reaction sequence involves microwave-induced preparation of N-(2-oxo-1,2-dihydro-3’H-indol-3-ylidene)pyridine-4-carbohydrazide [3] from isoniazid [1] and isatin [2] followed by the cyclo condensation of [3] and mercaptoacetic acid under microwave condition to achieve the synthesis of spiro-[indole-thiazolidine] derivatives [4]. The resulting compounds were then allowed to react with various aromatic and heterocyclic aromatic aldehydes to afford arylidene derivatives [5a-l]. Result: Isoniazid (1) on condensation with isatin (2) in the presence of catalytic amount of glacial acetic acid furnished N-(2-oxo-1,2-dihydro-3’H-indol-3-ylidene)...
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关键词翻译
关键词翻译
  • arylidene 芳叉
  • carbohydrazide 碳酰肼
  • aldehydes 
  • pyridine 吡啶
  • derivatives 派生物
  • cyclization 环化
  • heterocyclic 杂环的
  • reaction 反酌
  • anhydrous 无水的
  • afford 提供