EFFECT OF WATER CONTENT IN KNEADING METHOD OF SOLID DISPERSION TECHNIQUE FOR SOLUBILITY ENHANCEMENT
作者: Shankarguru P.Ramya Devi D.Vedha Hari Bn
作者单位: 1Department of Pharmaceutical Technology, School of chemical and Biotechnology, SASTRA University, Thanjavur 613401, Tamil Nadu, India. vedhahari@scbt.sastra.edu
刊名: International Journal of Applied Pharmaceutics, 2017, Vol.9 (5), pp.14-21
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijap.2017v9i5.17765
原始语种摘要: Objective: The main objective of the research work was to optimize the water requirement/content used in kneading method for solid dispersion/inclusion complex formation between water insoluble drug and polymer.Methods: Nimesulide (model drug) and β-cyclodextrin were taken in a different ratio such as 1:1, 1:3 and 1:5 and, the mixture was triturated well for half hour. Water was incorporated to the mixture in different levels like 75%, 50%, 25% w/v in divided proportions and 0% (no water addition, but the mixture was triturated continuously). After each part of water addition, the mixture was triturated well for 10 min and dried using hot air over for 30 min at 50 °C and sieved using sieve no: 44. The complexes formed were subjected for various analytical characterization studies...
全文获取路径: IAS 
分享到:

×
关键词翻译
关键词翻译
  • solubility 溶度
  • insoluble 不溶的
  • cyclodextrin 环糊精
  • mixture 混合物
  • water 
  • complex 超群
  • polymer 聚合物
  • gravimetric 重力的
  • incorporated 股份有限公司
  • particle 颗粒