DESIGN AND EVALUATION OF BUCCAL PATCHES CONTAINING COMBINATION OF HYDROCHLOROTHIAZIDE AND ATENOLOL
作者: Ashutosh RodaPrabhakara PrabhuAkhilesh Dubey
作者单位: 1Faculty of Pharmacy, Bhagwant University, Ajmer, Rajasthan, India. akhilesh_intas@rediffmail.com
刊名: International Journal of Applied Pharmaceutics, 2018, Vol.10 (2), pp.105-112
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijap.2018v10i2.24460
原始语种摘要: Objective: Buccal patch is a non-dissolving thin matrix modified release dosage form which was developed to administer into the unconscious and less co-operative patients.Methods: The mucoadhesive buccal patches of hydrochlorothiazide (HCZ) and atenolol (ATN) were prepared by solvent casting technique using various concentrations of sodium alginate, hydroxyl propyl methyl cellulose, carbopol 934P and sodium carboxy methyl cellulose polymer and polyvinyl alcohol as a backing layer. The formulated patches were evaluated for their physicochemical parameters like thickness, weight variation, surface pH, content uniformity, folding endurance, swelling percentage studies and tensile strength, in vitro and ex vivo drug permeation. Results: The infra-red (IR) spectra showed no interaction between...
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关键词翻译
关键词翻译
  • carbopol 聚羰乙烯
  • cellulose 纤维素
  • formulation 配方
  • found 创立
  • satisfactory 满意的
  • release 释放
  • permeation 渗透
  • sustained 持续的
  • buccal 口的
  • percentage 百分数