A PRESPECTIVE STUDY ON APOBEC PROTEIN FAMILY
作者: S. GEJALAKSHMIN. HARIKRISHNANS. KOMAL
作者单位: 1Faculty of Pharmacy, Department of Pharmaceutical Chemistry Dr. M. G. R. Educational and Research Institute, Velappanchavadi, Chennai-77. gejampharm@gmail.com
刊名: International Journal of Current Pharmaceutical Research, 2019, pp.15-18
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijcpr.2019v11i6.36345
原始语种摘要: Apobec is an apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like" is a family of deaminases. It has two types of APOBEC enzymes n-terminal of apobec enzyme and C-terminal of APOBEC enzyme. N-terminal domain is catalytic domain and C-terminal domain is a pseudo catalytic domain. Pathogen and cellular genome undergo mutation by human DNA cytosine to uracil deaminases. Three subtypes of APOBEC3D. APOBEC3F, APOBEC3G and APOBEC3H restrict human deficiency virus-1. Two APOBEC enzymes are the sources of somatic mutagenesis in cancer cells that drive tumor evolution and manifest clinically as theraphy resistance. This review of the APOBEC family will focus on an open question in regulation, namely what role the interactions of these proteins with RNA have in editing substrate...
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关键词翻译
关键词翻译
  • domain 领域
  • somatic 躯体的
  • mutagenesis 突变形成
  • catalytic 催化的
  • enzyme 
  • evolution 进化
  • family 
  • editing 编辑
  • allosteric 变构的
  • RNA ROYAL NEPAL AIRLINES CORP.