DEVELOPMENT AND VLAIDATION OF SIMPLE UV-SPECTROPHOTOMETRIC METHOD OF QUANTIZATION OF DIAZEPAM IN BULK DRUG AND SOLID DOSAGE FORMULATION USING MIXED SOLVENCY CONCEPT
作者: Sanjay JainR. K. MaheshwariR. K. NemaIndrajeet Singhvi
作者单位: 1N. M. T. Gujarati College of Pharmacy, Indore 452016. dr.smjain@rediffmail.com
刊名: International Journal of Current Pharmaceutical Research, 2017, Vol.9 (6), pp.15-17
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijcpr.2017v9i6.23421
原始语种摘要: Objective: Commonly used organic solvents for spectrophotometric analysis of water insoluble drugs are methanol, ethanol, chloroform, benzene, toluene etc. The main drawbacks of organic solvents include high cost, toxicity, and pollution. Organic solvents have numerous adverse effects caused by single exposure like dermatitis, headache, drowsiness, nausea, eye irritation and long term exposure causes serious effects such as neurological disorder, chronic renal failure, and liver damage. They should be replaced by other ecofriendly alternative sources.Methods: The present study is an attempt to show that solid can also be used to act as solvent precluding the use of organic solvents. A simple, safe and sensitive method of spectrophotometric determination of diazepam obeyed beers law in the...
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关键词翻译
关键词翻译
  • toxic 有毒的
  • suitable 合适的
  • diazepam 安定
  • effects 海员自身物品
  • present 出席的
  • determination 测定
  • range 射程
  • quality 品质
  • sensitive 灵敏的
  • formulation 配方