JANUS KINASE ENZYME (JAK) INHIBITORS AND RHEUMATOID ARTHRITIS: A REVIEW OF THE LITERATURE
作者: AYMAN ASKARIABDULLA KHALID NOURIHANA MORRISSEYPATRICK A. BALL
作者单位: 1The Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation Trust, SY10 7AG, United Kingdom. hana.morrissey@wlv.ac.uk
刊名: International Journal of Current Pharmaceutical Research, 2019, pp.11-14
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijcpr.2019v11i6.36343
原始语种摘要: Cytokines play an essential role in normal cell growth and the regulation of immune function. The emergence of Janus Kinase Enzyme inhibitors promises the start of a revolution in the treatment of several chronic diseases. Their efficacy and safety profile have been demonstrated in multiple trials and they have been licensed for the treatment of a number of diseases including RA and PsA. Moreover, the use of highly selective Janus Kinase Enzyme inhibitors is currently being studied aiming to reduce side effects compared with traditional JAKinibs, an example of that would be the recent FDA approved upadacitinib. The Janus Kinase Enzyme inhibitorsmay supplant the classical biologic agents in the treatment of autoimmune diseases, since they exhibitthe advantages of oral administration,...
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关键词翻译
关键词翻译
  • immunogenicity 致免疫性
  • immune 免疫的
  • cytokines 细胞浆移动
  • essential 本质的
  • demonstrated 探明的储量
  • reversibility 可逆性
  • treatment 处理
  • administration 管理
  • including 包括(气导)包括……在内包括…在内
  • being