DEVELOPMENT AND VALIDATION OF NOVEL RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF GABAPENTIN AND AMITRIPTYLINE HYDROCHLORIDE IN BULK AND PHARMACEUTICAL DOSAGE FORMS
作者: Sultana Gani Mohd ShaikhVandana Jain
作者单位: 1M.PHARM Student, Department of Quality Assurance, Oriental College of Pharmacy, Sanpada - Navi Mumbai, Maharashtra 400 705.. sultanaganimohd@gmail.com
刊名: International Journal of Applied Pharmaceutics, 2018, Vol.10 (2), pp.97-104
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijap.2018v10i2.24842
原始语种摘要: Objective: To develop a novel, accurate, precise and linear reverse phase high performance liquid chromatographic (RP-HPLC) method for simultaneous quantitative estimation of gabapentin and amitriptyline hydrochloride in gabantip-at tablet and validate as per international conference on harmonization (ICH) guidelines and to perform the force degradation studies using the developed method.Methods: In the present work, good chromatographic separation was achieved isocratically using a shim-pack HPLC C18 column (4.6 x 250 mm, 5μm) and mobile phase consisting of 0.05 M potassium dihydrogen orthophosphate pH 2.1 adjusted with orthophosphoric acid and acetonitrile in the ratio (55:45), at flow rate 1 ml/min and column temperature (25 °C). The effluents obtained were monitored at 221 nm with the...
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关键词翻译
关键词翻译
  • simultaneous 同时的
  • hydrochloride 盐酸盐
  • amitriptyline 阿米替林
  • values 价值观
  • perform 履行
  • degradation 减嚣夷酌
  • quality 品质
  • orthophosphate 磷酸盐
  • achieved 获得的
  • respectively 分别