FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF BUSPIRONE USING COPROCESSED SUPERDISINTEGRANTS
作者: SHALLY SHARMANIMRATA SETHNARESH SINGH GILL
作者单位: 1Department of Pharmaceutics, Rayat Institute of Pharmacy, Railmajra, Punjab, Department of Pharmaceutical Chemistry, Rayat Institute of Pharmacy, Railmajra, Punjab. shallysharma2731@gmail.com
刊名: International Journal of Current Pharmaceutical Research, 2019, pp.31-37
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijcpr.2019v11i5.35698
原始语种摘要: Objective: The present study aims to formulate and evaluate Fast dissolving tablet of Buspirone, the drug that is used for management of anxiety, by direct compression method using various Super disintegrants. Methods: Ten formulations (F1-F10) of fast dissolving tablets of Buspirone were prepared by using various Superdisintegrants. The prepared tablets were evaluated for hardness, friability, thickness, drug content uniformity, water absorption, wetting time, and disintegration time and in vitro dissolution study. Results: Among all the formulations, F10 (containing 5 mg of Coprocessed (CS: SSG 1:2) Superdisintegrants) was considered to be the best formulation, which released up to 98% drug in 20 min as compared to a marketed conventional dosage form which dissolves in approx 60 min....
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关键词翻译
关键词翻译
  • tablet 药片
  • FAST Facility For Automatic Sorting And Testing
  • compression 压缩
  • formulation 配方
  • uniformity 均匀性
  • dissolving 溶解
  • approx 大约
  • formulate 公式化
  • containing 包含的
  • hardness 硬度