AMELIORATIVE EFFECTS OF STEM BARK OF THE WONDER TREE, PROSOPIS CINERARIA (L.) DRUCE AGAINST LPS-INDUCED TOXICITY: AN IN VITRO STUDY
作者: VEENA SHARMAPREETI SHARMA
作者单位: 1Department of Bioscience and Biotechnology, Banasthali University, Rajasthan. drvsh@gmail.com
刊名: International Journal of Current Pharmaceutical Research, 2019, pp.96-102
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijcpr.2019v11i6.36352
原始语种摘要: Objective: The present experimental investigation was planned to unravel and analyze the therapeutic potential of hydro-ethanol extract prepared from the stem bark of Prosopis cineraria against LPS-induced toxicity under in vitro conditions. Methods: Liver tissue samples from healthy Swiss albino male mice (Mus musculus) were used for the study. Liver homogenate (0.9 ml) was treated with 0.05 mg/ml of LPS along with 0.01 to 0.05 mg/ml of hydro-ethanol plant extract and allowed to incubate at 37˚C. The reactions were terminated at different time points at 0 min, 30 min, 1 h, 2 h, 4 h, 8 h and 24 h and alterations in oxidative stress (LPO, CAT, SOD, GSH, GST, and GPx) and biochemical parameters of hepatic toxicity (AST and ALT, ACP and ALP) were studied. Results: The results demonstrated...
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关键词翻译
关键词翻译
  • LPS Laboratory Peripheral System
  • ethanol 乙醇
  • cineraria 瓜菊
  • toxicity 毒性
  • biochemical 生物化学的
  • oxidative 氧化的
  • treated 加工的
  • induced 感应的
  • therapeutic 治疗的
  • homogenate 均质