APPLICATION OF RESPONSE SURFACE METHODOLOGY IN OPTIMIZATION OF PACLITAXEL LIPOSOMES PREPARED BY THIN FILM HYDRATION TECHNIQUE
作者: Amol A. TatodeArun T. PatilMilind J. Umekar
作者单位: 1Department of Pharmaceutics, University Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra 440033, India. aatatode@rediffmail.com
刊名: International Journal of Applied Pharmaceutics, 2018, Vol.10 (2), pp.62-69
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijap.2018v10i2.24238
原始语种摘要: Objective: The present investigation was aimed to optimize the formula of paclitaxel-loaded liposomes (PTL) by using the application of response surface methodology (RSM).Methods: Paclitaxel-loaded liposome (PTL) was optimized by response surface methodology based on two parameters, namely, percent entrapment efficiency (% EE) and percent in vitro drug release at 12 h (% DR). The liposome formula was prepared using 32 factorial design, and the selected independent variables were, phospholipid (phospholipon 90G) and cholesterol (CH) concentrations. Nine formulas of paclitaxel-loaded liposome were prepared by thin film hydration technique (THF). The entrapment efficiency, in vitro release studies and drug content, were evaluated using on UV-visible spectrophotometer at λmax-230 nm. The...
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关键词翻译
关键词翻译
  • methodology 方法学
  • percent 百分率
  • formulas 公式
  • optimize 优选
  • variables 变量
  • entrapment 诱陷
  • loaded 加负荷的
  • efficiency 效率
  • developed 开发
  • phospholipid 磷脂