FORMULATION AND DEVELOPMENT OF MICROSPHERES FOR THE TREATMENT OF FAMILIAL ADENOMATOUS POLYPOSIS
作者: Md. GulshanM. Lakshmi Swapna SaiT. HemalathaU. Jhansi SriN. Ramarao
作者单位: 1Department of Pharmaceutics, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, Andhra Pradesh, India-522034. gulshan.md210@gmail.com
刊名: International Journal of Applied Pharmaceutics, 2017, Vol.9 (5), pp.66-72
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijap.2017v9i5.19731
原始语种摘要: Objective: Familial adenomatous polyposis (FAP) also known as familial polyposis coli, is a hereditary disease characterized by progressive appearance of numerous polyps mainly in the large intestine. Polyps are initially benign but can easily become cancerous and as such it is a life threatening condition. Celecoxib, a cyclooxygenase-2 (COX-2) inhibitor is thought to induce cell death, and thus prevent or delay the growth of polyps. So in the present study celecoxib loaded microspheres were prepared using control release Hydroxy propyl methyl cellulose (HPMC K4M) and pH dependent polymer eudragit L 100-55 in different ratios (1:1 to 1:4) respectively. The main objective of the study is to identify the polymer concentration required to prevent the drug release in stomach region and...
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关键词翻译
关键词翻译
  • polyposis 息肉病
  • adenomatous 腺瘤的
  • hereditary 遗传性
  • stomach 
  • cancerous 癌性的
  • density 密度
  • loaded 加负荷的
  • cellulose 纤维素
  • found 创立
  • dissolution 溶解