FORMULATION AND OPTIMIZATION OF ITRACONAZOLE PRONIOSOMES USING BOX BEHNKEN DESIGN
作者: Ahmed M. SamyAfaf A. RamadanAmal S.m. Abu El-eninYasmin I. M. Mortagi
作者单位: 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Nasr City, Cairo, Egypt. yasmin.mohamed@su.edu.eg
刊名: International Journal of Applied Pharmaceutics, 2018, Vol.10 (2), pp.41-51
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijap.2018v10i2.23382
原始语种摘要: Objective: The aim of the present study was to obtain an optimized formula of itraconazole (ITC) proniosomes using Box Behnken design.Methods: Itraconazole proniosomes were prepared using span 60 and/or brij 35 as surfactants, cholesterol and lecithin as a penetration enhancer by slurry method. Various trials have been carried out for investigation of proniosomes. Parameters such as entrapment efficiency (EE%), in vitro drug release, zeta potential, vesicle size and Transmission Electron Microscope were assessed for evaluation of proniosomes.Results: Entrapment efficiency (EE%) was found to be between 78.56% and 95.46%. The release profile of itraconazole proniosomes occurred in two distinct phases, an initial phase for about 8 h, followed by a slow phase for 16 h. The release pattern...
全文获取路径: IAS  (合作)
分享到:

×
关键词翻译
关键词翻译
  • efficiency 效率
  • initial 开首字母
  • potential 
  • values 价值观
  • entrapment 诱陷
  • formulation 配方
  • range 射程
  • release 释放
  • optimization 最佳化
  • effects 海员自身物品