STABILITY INDICATING METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS QUANTIFICATION OF SORAFENIB AND REGORAFENIB DRUG SUBTANCES BY USING RP-UPLC
作者: VIDYASAGAR CHOPPELLARAGHU BABU K.SURESH BADIPATIHARITHA GONTHINAVENKATA KISHORE CHUKKA
作者单位: 1Department of Engineering Chemistry, Andhra University College of Engineering (A), Andhra University, Visakhapatnam, Andhra Pradesh, India. vidyasagarchoppella@gmail.com
刊名: International Journal of Current Pharmaceutical Research, 2020, pp.56-62
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijcpr.2020v12i1.36832
原始语种摘要: Objective: The aim of the research work is to develop and validate a novel, sensitive, specific, rapid, accurate, precise and stability indicating gradient reverse phase ultra-performance liquid chromatography (RP-UPLC) method for the quantitative determination of sorafenib and regorafenib drug substances. Methods: Liquid chromatographic method used for the analysis of the anti-cancer drug substances like sorafenib and regorafenib and method was developed and validated by using efficient chromatographic separation method and was achieved with the use of acquity UPLC system was used consisting of quaternary pump, photodiode array detector an auto injector and on line degasser. Results: The separation was achieved using acquity UPLC BEH C18, 1.7 µm.2.1×50 mm analytical column at 30 °C...
全文获取路径: IAS  (合作)
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关键词翻译
关键词翻译
  • photolytic 光解的
  • achieved 获得的
  • solution 溶液
  • aqueous 水的
  • simultaneous 同时的
  • quality 品质
  • injector 注射器
  • hydrolysis 水解
  • limits 范围
  • acceptable 可接受的