MICROWAVE ASSISTED SYNTHESIS OF TETRAHYDROPYRMIDINE AND IN SILICO SCREENING OF ANTIDIABETIC DRUG
作者: GEJALAKSHMI S.HARIKRISHNAN N.THILLAI GOVINDARAJAN G. E.DIVYASRI A.
作者单位: 1Faculty of Pharmacy, Department of Pharmaceutical Chemistry, DR. M. G. R. Educational and Research Institute, Velappanchavadi, Chennai-77. gejampharm@gmail.com
刊名: International Journal of Current Pharmaceutical Research, 2020, pp.10-13
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijcpr.2020v12i1.36821
原始语种摘要: Objective: To detect the microwave-assisted synthesis of Tetrahydropyrimidine derivative and its molecular docking studies for Diabetes. Methods: The Bignelli condensation method was used for Tetrahydropyrimidine derivative synthesis. The docking studies made in Argus Lab software. Results: The Tetrahydropyrimidine is synthesized using the microwave. The Tetrahydropyrimidine derivative is found to be attack the insulin receptor, as it the tendency of binding with insulin receptor showed in Argus lab. Further, the good binding site of Tetrahydropyrimidine derivative with insulin receptor was predicted. Conclusion: From the research work, The Tetrahydropyrimidine derivative shows its affinity to bind with the insulin receptor. The binding value is averagely 7 which indicates it can...
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关键词翻译
关键词翻译
  • derivative 衍生物
  • insulin 胰岛素
  • docking 靠泊
  • receptor 接受体
  • Argus 阿格斯牌照相机
  • synthesis 合成
  • affinity 亲和力
  • altering 修改
  • binding 装订
  • secretion 分泌