DEVELOPMENT AND VALIDATION OF HPTLC METHOD FOR DETERMINATION APIXABAN IN BULK AND TABLETS
作者: Hemant K. JainVishal K. Nikam
作者单位: 1Department of Quality Assurance Techniques, Sinhgad College of Pharmacy, Vadgaon (Bk.), Pune 411041, Maharashtra, India. hemantkjain2001@yahoo.co.in
刊名: International Journal of Applied Pharmaceutics, 2017, Vol.9 (5), pp.78-82
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijap.2017v9i5.20028
原始语种摘要: Objective: To develop a simple and sensitive, high-performance thin layer chromatographic (HPTLC) method for the quantitative estimation of apixaban in bulk and tablets.Methods: Sample of apixaban was applied on silica gel 60 F254 TLC plates under pure nitrogen stream by linomat TLC applicator. Separation was carried out by using toluene, methanol and diethylamine as a mobile phase in a ratio of 16:3:1 v/v/v. Developed TLC plates were scanned by camag TLC scanner and detection was carried out at 288 nm.Results: Rf value of apixaban was found to be 0.4. The linearity was found from 50 to 350 ng/spot. The mean percentage recovery was found to be 85.66with % RSD of 0.79.Conclusion: The present study represents first HPTLC method that deals with the estimation of apixaban. Validation results...
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关键词翻译
关键词翻译
  • HPTLC 高效薄层色谱法
  • nitrogen 
  • tablet 药片
  • ratio 
  • recovery 回收
  • value 
  • carried 携带
  • various 千变万化的
  • sensitive 灵敏的
  • stream