AMELIORATIVE ROLE OF SILYMARIN AGAINST ASPARTAME–INDUCED BIOCHEMICAL CHANGES, OXIDATIVE STRESS, INFLAMMATORY EFFECT AND GENOTOXICITY IN MALE ALBINO RATS
作者: SABHA E. ELBALLATAL-SHIMAA M. ABAS
作者单位: 1Zoology Department, Faculty of Science, Zagazig University, Egypt. dr_shmma@yahoo.com
刊名: International Journal of Current Pharmaceutical Research, 2020, pp.41-55
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijcpr.2020v12i1.36831
原始语种摘要: Objective: Aspartame (ASP) is one of the most common artificial sweeteners. It has been recorded to be safe by World Health Organization. However, numerous publications have concluded that ASP is a genotoxic and carcinogenic sweetener. Methods: The current study aims to examine the effect of ASP consumption (250 mg/kg body weight/day for 90 d) on some biochemical parameters, oxidative/antioxidative status in different tissues, Tumor Necrosis Factor-α (TNF-α), chromosomal aberration (CA) frequency and mitotic index (MI) percentage in addition to the possible ameliorative role of silymarin (50 mg/kg body weight/day for 90 d) against ASP-induced toxicity in male albino rats. Results: The present results have confirmed that ASP is able to induce significant increase in the blood glucose...
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关键词翻译
关键词翻译
  • STRESS 压力
  • induced 感应的
  • albino 白化体
  • ameliorative 改良的
  • against 反对
  • biochemical 生物化学的
  • administration 管理
  • ASP Advanced Signal Processing
  • oxidative 氧化的
  • silymarin 水飞蓟素