FORMULATION DEVELOPMENT AND CHARACTERIZATION OF GASTRORETENTIVE DRUG DELIVERY SYSTEMS OF LORATADINE
作者: SRINU NAIK SAPAVATURAJENDRA KUMAR JADI
作者单位: 1Department of Chemical Engineering, University College of Technology, Osmania University, Hyderabad 500007, Telangana State, India. rajendra.rajaji@gmail.com
刊名: International Journal of Applied Pharmaceutics, 2019, pp.91-99
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijap.2019v11i6.35194
原始语种摘要: Objective: The main objective of the research work is to develop a single unit non-effervescent drug delivery system of Loratadine (LTD) by direct compression process to prolong the gastric residence time (GRT). Methods: LTD non-effervescent tablets were prepared with different polymers like hydroxypropyl methylcellulose (HPMC) K15M, HPMC K100M (i.e.: 1:1, 1:2, 1:3) as release retardants. Glyceryl behenate (Compritol 888 ATO) and Glyceryl palmitostearate (Precirol ATO 5) were used (1:1, 1:2, 1:3) as low-density lipids to impart buoyancy for longer period. Results: The drug (LTD) and excipient (i.e. HPMC, low-density lipid aids, etc.,) interaction studies were carried out by Fourier Transform Infrared Spectroscopy (FTIR) and there was no likely interaction involving them. The developed LTD...
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关键词翻译
关键词翻译
  • effervescent 起泡的
  • tablets 平片体
  • excipient 赋形剂
  • formulation 配方
  • density 密度
  • radiographic 射线照相的
  • release 释放
  • prolong 拉长
  • compression 压缩
  • lipid 脂质