DEVELOPMENT, EVALUATION AND CHARACTERISTICS OF OPHTHALMIC IN SITU GEL SYSTEM: A REVIEW
作者: MRINMOY DEKAABDUL BAQUEE AHMEDJASHOBIR CHAKRABORTY
作者单位: 1Girijananda Chowdhury Institute of Pharmaceutical Science (GIPS), Hatkhowapara, Azara, Guwahati 781017 Assam. mrinmoyprincedeka@gmail.com
刊名: International Journal of Current Pharmaceutical Research, 2019, pp.47-53
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijcpr.2019v11i4.34949
原始语种摘要: Eye is a sensitive organ and is easily injured and infected. Delivery of drugs into eye is complicated due to removal mechanism of precorneal area results decrease in therapeutic response. Conventional ocular delivery systems like solution, suspension, ointment shows some disadvantages such as rapid corneal elimination, repeated instillation of drug and short duration of action. In situ polymeric delivery system will help to achieve optimal concentration of drug at the target site, thereby helps to achieve the desired therapeutic concentration. There are various novel ocular drug delivery systems such as In-situ gel, dendrimers, niosomes, nanoparticulate system, collagen shield, ocular iontophoresis suspension and ocusert etc. In situ gelling systems are liquid upon instillation and...
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关键词翻译
关键词翻译
  • ophthalmic 眼的
  • instillation 滴注
  • ocular 目镜
  • therapeutic 治疗的
  • delivery 移交
  • concentration 浓度
  • removal 消去
  • systems 系统科学与软件
  • towards 朝向
  • transition 转移