THE HYPOGLYCAEMIC EFFECT OF OLEANONIC ACID ISOLATED FROM PILEA ELIZABETHAE IN A RAT MODEL
作者: Ruby Alexander LindoColeen SalmonDonovan Mcgrowder
作者单位: 1Department of Basic Medical Sciences, Faculty of Medical Sciences, the University of the West Indies, Kingston 7, Jamaica, West Indies. lisa.lindo@uwimona.edu.jm
刊名: International Journal of Current Pharmaceutical Research, 2017, Vol.9 (6), pp.63-69
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijcpr.2017v9i6.23431
原始语种摘要: Objective: The objective of this study is to isolate and identify the chief hypoglycaemic component of Pilea elizabethaeMethods: The chief hypoglycaemic component of Pilea elizabethaewas isolated and identified. The bio-directed purification of the chief hypoglycaemic agents contained in Pilea elizabethae followed a sequence of steps alternating oral glucose tolerance test (OGTT) bioassay and chromatographic methods. The ethyl acetate crude extract which was most hypoglycaemic in activity was flash chromatographed on silica gel using a gradient hexane-ethyl acetate solvent system of increasing polarity. Elucidation of the chemical structures of R-E2Gii was determined using NMR and FT-IR spectroscopy, melting point determination and comparison with literature. The Pilea elizabethae...
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关键词翻译
关键词翻译
  • prandial 膳食的
  • OGTT 口服葡萄糖耐量试验
  • acetate 醋酸盐
  • hyperglycaemia 高8糖
  • extracts 摘记
  • purification 提纯
  • glibenclamide 格列本脲
  • spectroscopy 分光学
  • glucose 葡萄糖
  • resonance 共振