PROTOTYPE SELF EMULSIFYING SYSTEM OF ETRAVIRINE: DESIGN, FORMULATION AND IN VITRO EVALUATION
作者: G. B. PreethiH. N. ShivakumarM Ravi KumarN Sweta
作者单位: 1Department of Pharmaceutics, KLEU College of Pharmacy, BENGALURU. preethigb.mmm@gmail.com
刊名: International Journal of Applied Pharmaceutics, 2018, Vol.10 (2), pp.13-19
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijap.2018v10i2.22714
原始语种摘要: Objective: Lipid-based formulations have gained much attention, particularly on self-emulsifying drug delivery systems (SEDDS), to improve the oral bioavailability of lipophilic drugs. In the present study, an attempt was made to develop and evaluate prototype SEDDS of poorly soluble antiviral BCS class IV drug etravirine.Methods: Various oils, surfactants and co-surfactants were screened for their suitability in the formulation of SEDDS. Based on the screening, gelucire 44/14, as the oil, labrasol as a surfactant and transcutol HP as the co-surfactant were selected. SEDDS with drug etravirine was formulated and evaluated for emulsifying ability, dilution potential and microscopic properties. The emulsion area for each of the combination of oil and surfactant co-surfactant mixture (Smix)...
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关键词翻译
关键词翻译
  • formulation 配方
  • emulsifying 乳化的
  • indicating 指示
  • dissolution 溶解
  • construction 构造
  • DESIGN 指定
  • uniformity 均匀性
  • illustrated 以…说明
  • class 
  • dilution 稀度