RUTIN RESTORE BIOCHEMICAL CHANGES, OXIDATIVE STRESS AND BETATROPHIN LEVEL IN STZ-INDUCED DIABETIC RATS
作者: AL-SHIMAA M. ABASAHMED F. EL-FARAFGNEHAL W. ABDALLA
作者单位: 1Biochemistry Division, Chemistry Department, Faculty of Science, Zagazig University, Egypt. dr_shmma@yahoo.com
刊名: International Journal of Current Pharmaceutical Research, 2019, pp.62-70
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijcpr.2019v11i6.36344
原始语种摘要: Objective: Diabetes mellitus (DM) is associated with long-term damage, dysfunction, of various organs. Study aims to assessrole of rutin on experimentally induced diabetes. Methods: 50 adult male albino rats divided into 5 groups. Group I (control group, rats were orally administered with 1 ml saline daily). Group II (DMSO group, rats were orally administered with 0.2 % DMSO for 60 d orally). Group III (positive control, animals were injected intraperitoneally with 60 mg/kg b. wtstreptozotocin followed by intraperitoneal injection with 120 mg/kg b. wt of Nicotinamide after 15 min). Group IV (therapeutic group, diabetic rats treated with 100 mg/kg b. wt of rutin for 60 d orally). Group V (standard group, diabetic animals treated with 100 mg/kg b. wt of metformin for 60 d orally). At the...
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关键词翻译
关键词翻译
  • diabetic 糖尿病患者
  • streptozotocin 链脲佐菌素
  • STRESS 压力
  • metformin 二甲双胍
  • rutin 芸香苷
  • triglyceride 甘油三酯
  • diabetes 糖尿病
  • induced 感应的
  • creatinine 肌酸酐
  • cholesterol 胆甾醇