SOLUBILITY ENHANCEMENT OF GLIBENCLAMIDE USING MESOPOROUS SILICA
作者: Swati Mittal AKSHAY SONAWANE MANGESH KHUNE
作者单位: 1VES College of pharmacy, Chembur, Mumbai. mangeshkhune4mk@gmail.com
刊名: Asian Journal of Pharmaceutical and Clinical Research, 2019, pp.302-314
来源数据库: Innovare Academics Sciences PVT.Ltd.
原始语种摘要: Glibenclamide is a BCS Class II drug and poses a major problem during formulation development. In the present study, adsorption onto various carriers was used to enhance the solubility of glibenclamide. It was observed that solubility of glibenclamide was greatly enhanced by adsorbing onto mesoporous silica. The increase in solubility of poorly soluble drugs is often associated with the generation of supersaturation, which results in the risk of drug precipitation. HPMC E5 was used as precipitation inhibitor to maintain sink condition for a longer duration. A 32 full factorial design was adopted to optimize the ratio of glibenclamide (X1) and mesoporous silica as a carrier (X2) and the effect of different ratios was studied on percent yield, percent drug loading, and percent drug release....
全文获取路径: IAS  (合作)
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关键词翻译
关键词翻译
  • glibenclamide 格列本脲
  • tablets 平片体
  • precipitation 沉淀
  • solubility 溶度
  • release 释放
  • percent 百分率
  • adsorbate 吸附质
  • adsorbing 吸附的
  • formulation 配方
  • silica 硅土