NANOSPHERE-LOADED TADALAFIL WITH ENHANCED ORAL BIOAVAILABILITY: INNOVATIVE APPLICATION OF ELECTROHYDRODYNAMIC TECHNIQUE
作者: MOHAMMED M. MEHANNAJANA K. ALWATTAR
作者单位: 1Department of Pharmaceutical Technology, Faculty of Pharmacy, Beirut Arab University, Beirut, Lebanon, Egypt, 21521. mmhanna@bau.edu.lb
刊名: International Journal of Current Pharmaceutical Research, 2020, pp.28-34
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijcpr.2020v12i1.36828
原始语种摘要: Objective: Electrohydrodynamic atomization is a technique that utilizes electrical potential differences for the fabrication of particles ranging from nano to micrometer size, where the ultra-charged droplets of drug-loaded mist deposit as nanospheres after solvent evaporation. The drug-loaded polymeric spherical nanocomposites have a small volume with large surface area, which is a beneficial characteristic for dissolution and bioavailability enhancement of class II drugs. Methods: This facile approach is employed for the preparation of tadalafil-loaded nanosystems, a class II drug used for erectile dysfunction treatment. Tadalafil-loaded nanoparticles prepared with different polymer concentrations were evaluated through process yield, drug loading, morphology and functional performance....
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关键词翻译
关键词翻译
  • loaded 加负荷的
  • micrometer 测微计
  • diffraction 衍射
  • loading 加负载
  • spherical 球的
  • morphology 形态学
  • evaporation 蒸发
  • fabrication 制造
  • amorphous 非晶质的
  • dissolution 溶解