DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF AZILSARTAN MEDOXOMIL AND CHLORTHALIDONE IN BULK AND TABLET DOSAGE FORM
作者: S. S. AherR. B. SaudagarHemant Kothari
作者单位: 1R. G. Sapkal College of Pharmacy, Anjaneri, Nashik,. smitarohokale@yahoo.com
刊名: International Journal of Current Pharmaceutical Research, 2018, Vol.10 (6), pp.21-24
来源数据库: Innovare Academics Sciences PVT.Ltd.
DOI: 10.22159/ijcpr.2018v10i6.30967
原始语种摘要: Objective: A simple, precise, accurate method was developed for the simultaneous estimation of azilsartan and chlorthalidone in bulk and tablet dosage form by RP-HPLC technique.Methods: Acetonitrile and water in the ratio of (70:30) pH 2.8 used as mobile phase run through (Cosmosil C18 (4.6ID x 250 mm, Particle size: 5 micron) column with a flow rate of 0.9 ml/min. The temperature of the column oven was maintained at 30 °C. Wavelength was selected 244 nm. Stock and working solutions were prepared by using the diluents water and acetonitrile in the ratio of 50:50. Runtime was fixed to 9 min.Results: Chlorthalidone and azilsartan were eluted at 2.02 and 3.92 with good resolution the plate count, tailing factor and all system suitability parameters are within ICH range. Azilsartan Medoxomil...
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关键词翻译
关键词翻译
  • chlorthalidone 氯噻酮
  • found 创立
  • tablet 药片
  • suitability 适应
  • acetonitrile 乙腈
  • range 射程
  • retention 保留
  • parameters 参数
  • column 
  • within 在以内