Current Status of Anti Epidermal Growth Factor Receptor Therapy in the Curative Treatment of Head and Neck Squamous Cell Carcinoma
作者: Cessal Thommachan Kainickal
刊名: Cancer Studies and Molecular Medicine - Open Journal, 2016, Vol.3 (1)
来源数据库: Openventio Publishers
DOI: 10.17140/CSMMOJ-3-114
关键词: Epidermal growth factor receptor (EGFR)Head and neck-targeted therapy.
原始语种摘要: Squamous cell carcinoma of head and neck is the most common malignancy of the upper aero digestive tract in the world. In this article, we attempt to summarize the role of antiepidermal growth factor therapy (EGFR) in the treatment of locally advanced head and neck squamous cell carcinoma. Cetuximab plus radiotherapy is a reasonable alternative in patients who cannot tolerate standard concurrent chemoradiotherapy (CTRT). There is no benefit by adding targeted therapy in addition to standard CTRT. Trials evaluating the role of targeted agents in the adjuvant setting showed no benefit in patients with high risk features; in addition to standard post-operative CTRT. Role of adjuvant monoclonal antibody in patients with intermediate risk factors is being evaluated.
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  • targeted 对准目标的
  • carcinoma 癌症
  • malignancy 恶性
  • adjuvant 辅助剂
  • squamous 具鳞的
  • radiotherapy 放射线疗法
  • digestive 消化道
  • concurrent 并发的
  • monoclonal 单细胞系的
  • factor 因素