From Schizophrenia Genetics to Disease Biology: Harnessing New Concepts and Technologies
作者: Jubao Duan 12 * Alan R. Sanders 12 Pablo V. Gejman 12
刊名: Journal of Psychiatry and Brain Science, 2019, Vol.4 (5)
来源数据库: Hapres
DOI: 10.20900/jpbs.20190014
关键词: SchizophreniaGeneticsGenome-wide association studyFunctional genomicsEpigenomicsChromatin modificationModel organismHuman induced pluripotent stem cells (hiPSCs)Genome editing
原始语种摘要: Schizophrenia (SZ) is a severe mental disorder afflicting around 1% of the population. It is highly heritable but with complex genetics. Recent research has unraveled a plethora of risk loci for SZ. Accordingly, our conceptual understanding of SZ genetics has been rapidly evolving, from oligogenic models towards polygenic or even omnigenic models. A pressing challenge to the field, however, is the translation of the many genetic findings of SZ into disease biology insights leading to more effective treatments. Bridging this gap requires the integration of genetic findings and functional genomics using appropriate cellular models. Harnessing new technologies, such as the development of human induced pluripotent stem cells (hiPSC) and the CRISPR/Cas-based genome/epigenome editing approach...
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关键词翻译
关键词翻译
  • genetic 遗传的
  • pluripotent 多能的
  • functional 功能的
  • understanding 理解
  • organism 生物
  • editing 编辑
  • fundamentally 从根本上
  • oligogenic 寡基因的
  • association 联合
  • induced 感应的