Inferring Very Recent Population Growth Rate from Population-Scale Sequencing Data: Using a Large-Sample Coalescent Estimator
作者: Chen HuaHey JodyChen Kun
刊名: Molecular Biology and Evolution, 2015, Vol.32 (11), pp.2996-3011
来源数据库: Royal Society
DOI: 10.1093/molbev/msv158
关键词: genetics diversitypopulation growth ratelarge-sample sequencingcoalescent
原始语种摘要: Large-sample or population-level sequencing data provide unprecedented opportunities for inferring detailed population histories, especially recent demographic histories. On the other hand, it challenges most existing population genetic methods: Simulation-based approaches require intensive computation, and analytical approaches are often numerically intractable when the sample size is large. We propose a computationally efficient method for simultaneous estimation of population size, the rate, and onset time of population growth in the very recent history, using the pattern of the total number of segregating sites as a function of sample size. Coalescent simulation shows that it can accurately and efficiently estimate the parameters of recent population growth from large-scale data. This...
全文获取路径: The Royal Society 
影响因子:10.353 (2012)

  • population 母体
  • Growth 生长
  • segregating 分开
  • growth 生长
  • recent 近来的
  • large 大的
  • published 公布的
  • intractable 不治的
  • numerically 数字上
  • flexibility 柔顺性