|作者：||Bruna Piassi Guaitolini, Priscilla Filippo Alvim de Minas Santos, Davisson do Sacramento de Lucena Tavares|
1Second-year Resident Physician in Pediatrics at the Central ArmyHospital, Rio de Janeiro.
2Master’s Degree Candidate at the Graduate Program in Medical Sciences,Rio de Janeiro State University. Specialist in Pediatrics accredited by theBrazilian Medical Association and Brazilian Society of Pediatrics. Specialist inAllergy and Immunology accredited by the Brazilian Medical Association andBrazilian Association of Allergy and Immunology. Allergist and Immunologist atHospital Municipal Jesus, Rio de Janeiro.
3Specialist in Allergy and Immunology accredited by the Brazilian MedicalAssociation and Brazilian Association of Allergy and Immunology. Allergist andImmunologist at Hospital Municipal Jesus, Rio de Janeiro.
|刊名：||Residência Pediátrica, 2019, Vol.9 (1), pp.15-18|
|来源数据库：||Brazilian Society of Pediatrics|
|关键词：||IgA Deficiency; Asthma; Rhinitis;|
|原始语种摘要：||Abstract Introduction: Selective IgA deficiency is the most common primary immunodeficiency, with aprevalence of 1/600 in Caucasians. Although most affected individuals areasymptomatic, symptomatic patients may present with recurrent infections,allergic diseases, autoimmune diseases and neoplasias. Objective: To report a case series of patients with IgA deficiency. Methods: Revisionof medical records of children and adolescents with confirmed diagnosis ofselective IgA deficiency, attended at the Reference center for asthma, at apediatric hospital in Rio de Janeiro, during the last 3 years. Results: Four patients with selective IgA deficiency were evaluated. The mean age was12 years, with two males. All had rhinitis/asthma. In addition to positivefamily history for atopy, high total IgE,... peripheral blood eosinophilia,with serum levels of IgA <7mg/dL, normal IgG and IgM, and EPF negative.No patient had autoimmune diseases, neoplasms, family immunodeficiencyhistory or consanguinity between parents. Two patients reported a history ofautoimmune diseases, one of neoplasia in the family. Recurrent infectionswere found in two patients. At the moment, all are in use of nasalcorticosteroid, one patient using oral inhaled corticosteroid and one, usingbronchodilator associated with oral inhaled corticosteroid with control ofrespiratory and infectious symptoms. Conclusion: Although the evolution of IgA deficiency is benign, patients should beregularly followed for recurrent and allergic infectious conditions asobserved in the patients studied.|