|作者：||Gabriela de Carvalho Nunes, Mauricio Obal Colvero|
1Pediatrician, Resident Physician in Neonatology, University ClinicsHospital, Porto Alegre (HCPA/UFRGS).
2PhD in Pediatrics at the Pontifical Catholic University of Rio Grande doSul; Head of Neonatal ICU of Hospital Fêmina, GHC.
|刊名：||Residência Pediátrica, 2019, Vol.9 (1), pp.29-35|
|来源数据库：||Brazilian Society of Pediatrics|
|关键词：||Infant; Premature Infant; Premature; Diseases Glucocorticoids Infant; Very Low Birth Weight;|
|原始语种摘要：||Abstract Introduction: The benefits of antenatal corticosteroid (AC) to preterm infants are wellestablished. Its action in multiple tissues promotes maturity of fetalstructures, with significant impact in the reduction of neonatalmorbimortality. Objective: Evaluate the effects of AC in very low birth weight preterm infants(VLBWPI). Methods: Data from the Rede Gaúcha de Neonatologia of those VLBWPI bornbetween 01/01/2008 and 12/31/2014 at the Fêmina Hospital in PortoAlegre was used. The exposure to AC (one or two doses of intramuscular 12mgbetamethasone) and its relation to mortality and following comorbiditieswere analyzed: respiratory distress syndrome (RDS), intraventricularhemorrhage (IVH), periventricular leukomalacia (PVL), retinopathy ofprematurity (ROP), necrotizing enterocolitis... (NEC), patent ductus arteriosus(PDA), and bronchopulmonary dysplasia (BPD). Results: A total of 496 patients were obtained, of whom 68% received at least onedose of CA and 32% received none. A significant reduction in the incidenceof RDS was obtained in the group that exposed to AC (OR 0.468, p = 0.001). A 60% reduction in IVH (OR 0.401, p < 0.001) was noted. A reduction inthe incidence of BPD was also observed with the use of AC (OR 0.296-0.903, p= 0.018). No statistical difference was observed in the incidence of PVL( p = 0.3), PDA ( p = 0.68), NEC ( p = 0.44) or ROP( p = 0.58). Neonatal death wassignificantly reduced by 78% in those treated with AC (OR 0.22, p < 0.001). Conclusion: exposure to AC, regardless of the number of doses, confers lower morbidityand lower mortality to VLBWPI.|