|作者：||Livia dos Santos Pires, Larrissa Nogueira de Freita, Leticia Baldez de Almeida, Livia Caroline Saviolo Cunha, Lohayne Marins Teixeira, Marleany Garcia Barros Mohallem Corrêa, Amanda Ramos Neves Araújo, Clarisse Pereira Dias Drumond Fortes|
1Aluno de graduação em medicina no CentroUniversitário de Volta Redonda (UniFOA).
2Aluna de Graduação de Medicina - UniFOA.
3Graduada em Medicina. Residente (R1) de Pediatria do Hospital SãoJoão Batista/Volta Redonda/ RJ.
4Mestre em Planejamento, Política e Administração emSaúde pelo Instituto de Medicina Social pela FM/ UERJ.Professora-assistente de pediatria para medicina do Centro Universitáriode Volta Redonda (UniFOA).
|刊名：||Residência Pediátrica, 2019, Vol.9 (1), pp.70-79|
|来源数据库：||Brazilian Society of Pediatrics|
|关键词：||Microcephaly; Genetic Diseases; Inborn; Flavivirus Infections; Congenital Abnormalities; Neurologic Manifestations;|
|原始语种摘要：||Abstract The brazilian Ministry of Health declared, in November 2015, national healthemergency due to an outbreak in Pernambuco of microcephaly in neoantes, with 268cases registration. This number is considerably higher than the average for theperiod 2010-2014, that was nine cases by year. Since then, it has increased thenumber of diagnoses of cases of microcephaly throughout the national territory,drawing the attention of experts and general population. According to the WorldHealth Organization (WHO), microcephaly is characterized by measuring the skullperformed by standard technical equipment and on the head circumference (HC)present as less than minus two (-2) standard deviations below the averagespecific for sex and gestational age. It also considers that the smallest asleast three... (-3) standard deviations is defined as severe microcephaly.Although, in the present context, an important part of microcephaly diagnoses isbeing linked to congenital infection Zika virus, microcephaly have complex andmultifactorial etiology. It may be related to genetic inheritance or syndromes,maternal malnutrition, use of drugs and drug use during pregnancy, metabolicsyndromes and congenital infections. This literature review aims to discuss theconcept, epidemiology, symptomatology and causes of microcephaly,contextualizing it in the current scenario of Zika virus infection.|