Recent advances in understanding and treating nephrotic syndrome
作者: Agnieszka BierzynskaMoin Saleem
作者单位: 1University of Bristol, Bristol Royal Hospital for Children, Bristol, UK
刊名: F1000Research, 2017, Vol.6
来源数据库: F1000 Research Ltd
DOI: 10.12688/f1000research.10165.1
关键词: idiopathic nephrotic syndromeminimal change nephrotic syndromeMCNSfocal segmental glomerulosclerosisFSGSSRNS
原始语种摘要: Idiopathic nephrotic syndrome (INS) is one of the most common glomerular diseases in children and adults, and the central event is podocyte injury. INS is a heterogeneous disease, and treatment is largely empirical and in many cases unsuccessful, and steroids are the initial mainstay of therapy. Close to 70% of children with INS have some response to steroids and are labelled as steroid-‘sensitive’, and the rest as steroid-‘resistant’ (also termed focal segmental glomerulosclerosis), and single-gene mutations underlie a large proportion of the latter group. The burden of morbidity is enormous, both to patients with lifelong chronic disease and to health services, particularly in managing dialysis and transplantation. The target cell of nephrotic syndrome is the glomerular podocyte, and...
全文获取路径: F1000 Research Ltd 

  • nephrotic 肾病的
  • podocyte 足状突细胞
  • understanding 理解
  • glomerular 肾小球病
  • steroid 甾族化合物
  • treating 处理
  • advances 预付款
  • therefore 因此
  • immune 免疫的
  • majority 多数