Metabolic reprogramming during the Trypanosoma brucei life cycle
作者: Terry K. SmithFrédéric BringaudDerek P. NolanLuisa M. Figueiredo
作者单位: 1Biomedical Sciences Research Complex, University of St Andrews, Fife, UK
2Laboratoire de Microbiologie Fondamentale et Pathogénicité (MFP), UMR 5234 CNRS, Université de Bordeaux, Bordeaux, France
3School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland
4Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
刊名: F1000Research, 2017, Vol.6
来源数据库: F1000 Research Ltd
DOI: 10.12688/f1000research.10342.1
关键词: Trypanosoma bruceimetabolismadaptations
原始语种摘要: Cellular metabolic activity is a highly complex, dynamic, regulated process that is influenced by numerous factors, including extracellular environmental signals, nutrient availability and the physiological and developmental status of the cell. The causative agent of sleeping sickness, Trypanosoma brucei , is an exclusively extracellular protozoan parasite that encounters very different extracellular environments during its life cycle within the mammalian host and tsetse fly insect vector. In order to meet these challenges, there are significant alterations in the major energetic and metabolic pathways of these highly adaptable parasites. This review highlights some of these metabolic changes in this early divergent eukaryotic model organism.
全文获取路径: F1000 Research Ltd  (合作)

  • reprogramming 改编程序
  • exclusively 专用于
  • eukaryotic 真核的
  • divergent 发散的
  • numerous 许多的
  • parasite 寄生物
  • these 这些的
  • organism 生物
  • metabolic 新陈代谢的
  • mammalian 哺乳动物