Recent advances in understanding context-dependent mechanisms controlling neurotrophin signaling and function
作者: Mark Bothwell
作者单位: 1Department of Physiology & Biophysics, University of Washington Medical Center, Seattle, WA, 98195-7290, USA
刊名: F1000Research, 2019, Vol.8
来源数据库: F1000 Research Ltd
DOI: 10.12688/f1000research.19174.1
关键词: Brain derived neurotrophic factorNeurotrophinBDNFTrkBP75NTRSynaptic plasticityDepressive disordersMemorySortilinSorCS2
原始语种摘要: Complex mechanisms control the signaling of neurotrophins through p75NTR and Trk receptors, allowing cellular responses that are highly context dependent, particularly in the nervous system and particularly with regard to the neurotrophin brain-derived neurotrophic factor (BDNF). Recent reports describe a variety of sophisticated regulatory mechanisms that contribute to such functional flexibility. Mechanisms described include regulation of trafficking of alternative BDNF transcripts, regulation of post-translational processing and secretion of BDNF, engagement of co-receptors that influence localization and signaling of p75NTR and Trk receptors, and control of trafficking of receptors in the endocytic pathway and during anterograde and retrograde axonal transport.
全文获取路径: F1000 Research Ltd 

  • 控制的 特别
  • neurotrophic 神经营养的
  • anterograde 顺行的
  • engagement 啮合
  • plasticity 可塑性
  • understanding 理解
  • signaling 发信号
  • factor 因素
  • particularly 特别
  • regulatory 特别
  • nervous 神经的