E3 ubiquitin ligase Mule targets β-catenin under conditions of hyperactive Wnt signaling
刊名: Proceedings of the National Academy of Sciences of the United States of America, 2017, Vol.114 (7), pp.E1148-E1157
来源数据库: JSTOR
关键词: Β-cateninMuleWnt signalingStem cellsColorectal cancer
原始语种摘要: Wnt signaling, named after the secreted proteins that bind to cell surface receptors to activate the pathway, plays critical roles both in embryonic development and the maintenance of homeostasis in many adult tissues. Two particularly important cellular programs orchestrated by Wnt signaling are proliferation and stem cell self-renewal. Constitutive activation of the Wnt pathway resulting from mutation or improper modulation of pathway components contributes to cancer development in various tissues. Colon cancers frequently bear inactivating mutations of the adenomatous polyposis coli (APC) gene, whose product is an important component of the destruction complex that regulates β-catenin levels. Stabilization and nuclear localization of β-catenin result in the expression of a panel of Wnt...
全文获取路径: JSTOR  (合作)

  • hyperactive 极度活跃的
  • signaling 发信号
  • ligase 连接酶
  • oncogenesis 肿瘤发生
  • ubiquitin 泛激素
  • polyposis 息肉病
  • pathway 轨道
  • adenomatous 腺瘤的
  • conditions 条件式
  • findings 结论