Sequence-, structure-, and dynamics-based comparisons of structurally homologous CheY-like proteins
刊名: Proceedings of the National Academy of Sciences of the United States of America, 2017, Vol.114 (7), pp.1578-1583
来源数据库: JSTOR
关键词: Amino acid physical propertiesProtein fluctuationsAll-atom simulations
原始语种摘要: We recently introduced a physically based approach to sequence comparison, the property factor method (PFM). In the present work, we apply the PFM approach to the study of a challenging set of sequences—the bacterial chemotaxis protein CheY, the N-terminal receiver domain of the nitrogen regulation protein NT-NtrC, and the sporulation response regulator Spo0F. These are all response regulators involved in signal transduction. Despite functional similarity and structural homology, they exhibit low sequence identity. PFM sequence comparison demonstrates a statistically significant qualitative difference between the sequence of CheY and those of the other two proteins that is not found using conventional alignment methods. This difference is shown to be consonant with structural...
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关键词翻译
关键词翻译
  • proteins 蛋白质
  • homologous 同结构型的
  • structure 构造
  • structurally 在结构上
  • dynamics 动力学
  • several 各自
  • physical 物理的
  • sequence 次序
  • functional 功能的
  • PFM Power Factor Meter