BMTP-11 is active in preclinical models of human osteosarcoma and a candidate targeted drug for clinical translation
刊名: Proceedings of the National Academy of Sciences of the United States of America, 2017, Vol.114 (30), pp.8065-8070
来源数据库: JSTOR
关键词: BMTP-11IL-11RαOsteosarcomaMouse modelsTarget therapy
原始语种摘要: Osteosarcoma occurs predominantly in children and young adults. High-grade tumors require multidisciplinary treatment consisting of chemotherapy in the neoadjuvant and adjuvant settings, along with surgical intervention. Despite this approach, death from respiratory failure secondary to the development and progression of pulmonary metastases remains a significant problem. Here, we identify the IL-11 receptor α subunit (IL-11Rα) as a cell surface marker of tumor progression that correlates with poor prognosis in patients with osteosarcoma. We also show that both IL-11Rα and its ligand, IL-11, are specifically up-regulated in human metastatic osteosarcoma cell lines; engagement of this autocrine loop leads to tumor cell proliferation, invasion, and anchorage-independent growth in vitro....
全文获取路径: JSTOR  (合作)
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关键词翻译
关键词翻译
  • osteosarcoma 骨肉瘤
  • preclinical 临证前期的
  • targeted 对准目标的
  • candidate 选择物
  • targeting 导向目标
  • human 人的
  • chemotherapy 化学疗法
  • combined 组合
  • translation 直移
  • prognosis 预报