Discovery of scmR as a global regulator of secondary metabolism and virulence in Burkholderia thailandensis E264
刊名: Proceedings of the National Academy of Sciences of the United States of America, 2017, Vol.114 (14), pp.E2920-E2928
来源数据库: JSTOR
关键词: Biosynthetic gene clustersNatural productsBurkholderia thailandensisRegulatioVirulence
原始语种摘要: Bacteria produce a diverse array of secondary metabolites that have been invaluable in the clinic and in research. These metabolites are synthesized by dedicated biosynthetic gene clusters (BGCs), which assemble architecturally complex molecules from simple building blocks. The majority of BGCs in a given bacterium are not expressed under normal laboratory growth conditions, and our understanding of how they are silenced is in its infancy. Here, we have addressed this question in the Gram-negative model bacterium Burkholderia thailandensis E264 using genetic, transcriptomic, metabolomic, and chemical approaches. We report that a previously unknown, quorum-sensing-controlled LysR-type transcriptional regulator, which we name ScmR (for secondary metabolite regulator), serves as a global...
全文获取路径: JSTOR  (合作)
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关键词翻译
关键词翻译
  • secondary 二次的
  • virulence 病毒性
  • regulator 第器
  • metabolism 代谢
  • repressor 阻遏因子
  • biosynthetic 生物合成
  • formation 建造
  • mutant 突变体
  • numerous 许多的
  • biofilm 生物薄膜