Interactions of Phagocytes with the Lyme Disease Spirochete: Role of the Fc Receptor
作者: Jorge L. BenachHoward B. FleitGail S. HabichtJames L. ColemanEdward M. BoslerBernard P. Lane
刊名: The Journal of Infectious Diseases, 1984, Vol.150 (4), pp.497-507
来源数据库: JSTOR
原始语种摘要: The phagocytic capacity of murine and human mononuclear and polymorphonuclear phagocytes (including peripheral blood monocytes and neutrophils), rabbit and murine peritoneal exudate cells, and the murine macrophage cell line P388DI against the Lyme disease spirochete was studied. All of these cells were capable of phagocytosing the spirochete; phagocytosis was measured by the uptake of radiolabeled spirochetes, the appearance of immunofluorescent bodies in phagocytic cells, and electron microscopy. Both opsonized and nonopsonized organisms were phagocytosed. The uptake of opsonized organisms by neutrophils was blocked by a monoclonal antibody specific for the Fc receptor and by immune complexes; these findings suggested that most phagocytosis is mediated by the Fc receptor. Similarly, the...
全文获取路径: JSTOR  (合作)
影响因子:5.848 (2012)

  • phagocytosis 噬菌
  • murine 鼠灰色
  • immune 免疫的
  • spirochete 螺旋原虫
  • monoclonal 单细胞系的
  • receptor 接受体
  • phagocytic 吞噬细胞的
  • antibody 抗体
  • against 反对
  • macrophage 巨噬细胞