Human Neutrophil FcγReceptor Distribution and Structure
作者: Howard B. FleitSamuel D. WrightJay C. Unkeless
刊名: Proceedings of the National Academy of Sciences of the United States of America, 1982, Vol.79 (10), pp.3275-3279
来源数据库: JSTOR
关键词: ImmunologyMonoclonal AntibodiesCell Surface AntigensMonocytesB and T LymphocytesPhagocytosis
原始语种摘要: Fc receptors (FcR) for IgG on human cells were analyzed with two monoclonal antibodies, 3G8 and 4F7. Fab fragments of both hybridoma IgGs inhibited binding to neutrophils of soluble rabbit IgG complexes and sheep erythrocytes (E) coated with rabbit IgG. The number of sites for 3G8 Fab was 135,000 per neutrophil, roughly equivalent to the number of sites for rabbit IgG in immune complexes (112,000 per cell). We did not observe human IgGl binding sites on neutrophils, although binding of IgGl to FcR-bearing lines U937 and HL-60 was readily demonstrated. Other cell types bearing 3G8 binding sites were mature chronic myelogenous leukemia cells, eosinophils, 6% of E-rosetting lymphocytes, and 15% of Ig-bearing peripheral lymphocytes. No binding of 3G8-Fab was observed on the FcR-bearing cell...
全文获取路径: JSTOR  (合作)
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关键词翻译
关键词翻译
  • rosetting 散开
  • hybridoma 杂交瘤细胞
  • monoclonal 单细胞系的
  • antigenic 抗原的
  • rabbit 
  • neutrophil 中性白细胞
  • binding 装订
  • IgG 免疫球蛋白 G
  • monocytes 单核细胞
  • mature 成孰的