This paper discussed the topic of genetic engineering option for persons with disabilities, to be or not to be. In this paper, the meaning of genetic engineering as a field of biotechnology, which deal with the modification of genes was discussed. The international regulations on genetic engineering on the rights of persons with disabilities were exposed; the issues against genetic engineering for persons with disabilities, which were based on limitation of children’s freedom, fears that genetic engineering will lead to eugenics, social inequalities, and possible environmental hazards were pointed out. The discourse highlighted the possible gains or merits of genetic engineering as a treatment option for persons with disabilities, also on children’s independence to rebuild their own... destinies, among others merits. Possible dangers of genetic engineering to persons with disabilities were discussed and the paper gave recommendations, inters alia, that there should be established regulations and published safety guidelines to reduce the dangers of researches on genetic engineering.