Preparation and Characterization of Terpenoid-Encapsulated PLGA Microparticles and its Antibacterial Activity against Enterococcus faecalis
作者: Denny NurdinAndri HardiansyahElsy Rahimi ChaldunAnti Khoerul FikkriyahHendra Dian Adhita DharsonoDikdik KurniaMieke Hemiawati Satari
作者单位: 1Universitas Padjadjaran
2Indonesian Institute of Sciences
3Faculty of Mathematics and Sciences, Universitas Padjadjaran
4Faculty of Dentistry, Universitas Padjadjaran
刊名: Key Engineering Materials, 2020, Vol.4790 , pp.263-269
来源数据库: Trans Tech Journal
DOI: 10.4028/
关键词: Drug Delivery SystemPLGATerpenoidEnterococcus Faecalis
原始语种摘要: Exploration of natural compound for the treatment of dental-related problems are gaining of interest for enhancing therapeutic efficacy of the drugs delivery system. In this study, we have prepared terpenoid, which have been isolated from Myrmecodia pendens Merr & Perry from Papua Island, Indonesia, to be encapsulated in Polylactic-co-glycolic acid (PLGA), as the most widely used biodegradable polymer for biomedical applications, through one step single-emulsion method followed by subsequent coating by poly (vinyl alcohol) (PVA). The resultant of terpenoid-loaded PLGA microparticles were characterized systematically through scanning electron microscope and Fourier-transform infrared spectroscopy. In vitro drug release test was evaluated through dialysis method. Antibacterial test was...
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  • against 反对
  • terpenoid 萜烯酯
  • loaded 加负荷的
  • biodegradable 生物降解的
  • developed 开发
  • release 释放
  • compartment 隔间
  • pendens 待决
  • bacterial 细菌的
  • gaining 担槽