Swelling Behavior and Drug Release of Polymer Coated Nano Iron Oxide Embedded Hydroxyapatite
作者: Yoshiyuki YokogawaRina OhkuraYoko InoueAtsumasa ShishidoEreath Beeran AnsarHari Khrisna Varma
作者单位: 1Osaka City University
2Sree Chitra Tirunal Institute for Medical Sciences and Technology
刊名: Key Engineering Materials, 2020, Vol.4790 , pp.108-113
来源数据库: Trans Tech Journal
DOI: 10.4028/www.scientific.net/KEM.829.108
关键词: Drug ReleaseHydroxyapatiteIron Oxide NanoparticleThermal Responsive Polymer
原始语种摘要: Spherical calcium-alginate gel beads containing HAIO, iron oxide (IO) nanoparticles embedded on hydroxapatite (HA), were prepared along with and poly (N-isopropylacrylamide) (PNIPAAM) or chitosan. These spheres, HAIO, HAIO-PNIPAAM and HAIO-chitosan spheres, were used as carriers of 5-fluorouracil (5-FU), one of the drugs for cancer chemical therapy, and the 5-FU release behavior in PBS solution was investigated at ambient and elevated temperatures using U-V spectrometry. The amount of the released 5-FU from the HAIO spheres was somewhat higher than that from HAIO-PNIPAAM and HAIO-chitosan spheres at ambient temperature. At elevated temperature, HAIO spheres showed an increase in quantity of released 5-FU. The amount of released 5-FU from HAIO-PNIPAAM spheres was almost the same, and that...
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  • chitosan 壳聚糖
  • alginate 藻蛋白酸盐
  • spheres 球状骨针
  • Release 免除释放机构
  • temperature 温度
  • release 释放
  • shell 贝壳
  • swelling 膨胀
  • amount 总计
  • chemical 化学的