The Large-Scale Production of Recombinant Human Serum Albumin in the Milk of Transgenic Cattle: Strategy & Implications
作者: Shaida Moghaddassi Will Eyestone Colin E. Bishop
刊名: Journal of Science and Applications: Biomedicine, 2014, Vol.2 (2)
来源数据库: International Union of Science and Education
关键词: BiopharmingTransgenic cattleMilkRecombinant human serum albuminTALENsHomologous recombinationSomatic cell nuclear transfer
原始语种摘要: The annual demand for therapeutic human serum albumin (HSA) is estimated to be more than 500 metric tons worldwide. As a major protein in the human body, HSA plays a vital role in many physiological processes, including the maintenance of oncotic pressure and the transportation of various biomolecules and pharmaceuticals. Currently, all HSA used for clinical blood expansion purposes is isolated from pooled human blood or plasma, an unpredictably fluctuating supply that can at times fall to dangerously low levels. Furthermore, this supply is derived from thousands of different donors and can potentially result in the spread of pathogenic contaminants to recipients. The use of transgenic animals, such as cattle, as living bioreactors, provides a potential solution to this problem by...
全文获取路径: Inter-USE  (合作)

  • cattle 
  • expression 表示
  • potentially 可能地
  • abundant 丰富的
  • recombinant 重组体
  • protein 蛋白质
  • endogenous 内成的
  • bovine 牛的
  • purification 提纯
  • times