Correlation between single nucleotide polymorphisms in microRNAs and hepatitis B virus-related hepatocellular carcinoma risk
作者: Guoming Su Jun Yang Liren Hu Zhuqing Fu Zuguo Zhao Weiqing Yang
刊名: Journal of Science and Applications: Biomedicine, 2015, Vol.3 (3)
来源数据库: International Union of Science and Education
关键词: MicroRNAsPolymorphismHepatitis B virusHepatocellular carcinomaMeta-analysis
原始语种摘要: We aimed to investigate the correlation between the four common single nucleotide polymorphisms (SNPs) in microRNAs (miR-146a rs2910164, miR-196a2 rs11614913, miR-499 rs3746444 and miR-149 rs2292832) and hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC) risk through a systematic review and meta-analysis. Odds ratios (ORs) along with 95% confidence intervals (95% CIs) were pooled to explore the strength of associations between SNPs in microRNAs and HBV-related HCC risk. All statistical analyses were performed using Stata 12.0 software. For miR-146a rs2910164, a significantly decreased risk of HBV-related HCC development was observed under recessive model (CC versus GC+GG: OR = 0.83, 95% CI 0.71-0.98, P = 0.03), and results remain robust in Asian populations. As for...
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关键词翻译
关键词翻译
  • nucleotide 核苷酸
  • related 有关的
  • hepatocellular 肝细胞性的
  • hepatitis 肝炎
  • genetic 遗传的
  • virus 病毒
  • carcinoma 癌症
  • observed 观察到的
  • single 单独的
  • between 在中间