Pharmacodynamic interaction of fenugreek with insulin and glimepiride in streptozotocin-induced oxidative stress in Sprague Dawley rats
作者: Haritha Chiluka Gopala Reddy Alla Ramana Reddy Yerradoddi Anil Kumar Banothu
刊名: Journal of Advanced Veterinary and Animal Research, 2015, Vol.Volume 2 (Issue 3)
来源数据库: Journal of Advanced Veterinary and Animal Research
DOI: 10.5455/javar.2015.b89
关键词: FenugreekGlimepirideInsulinOxidative stressProtein carbonylsTBARS
原始语种摘要: This study was aimed to assess the effect of fenugreek-insulin-glimepiride interaction on oxidative stress in streptozotocin-induced diabetic rats. A total of 56 male Sprague-Dawley rats were randomly divided into 7 groups (n=8); group 1: served as Sham, group 2: Diabetic control, groups 3, 4 and 5: served as individual treatment group, groups 6 and 7: treated with combination of insulin-fenugreek and glimepiride-fenugreek, respectively. Serum creatinine levels of the rats were estimated at 4th and 8th weeks during treatment. Thiobarbituric Acid Reactive Substances (TBARS), Glutathione (GSH) and protein carbonyls were estimated in the kidney homogenate, and relative kidney weights were measured at the end of the experiment. Present study indicated that the levels of TBARS and protein...
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  • streptozotocin 链脲佐菌素
  • insulin 胰岛素
  • fenugreek 胡芦巴
  • oxidative 氧化的
  • diabetic 糖尿病患者
  • stress 应力
  • creatinine 肌酸酐
  • significantly 较大地
  • treatment 处理
  • concentration 浓度