Single versus repeated tramadol injection in laparotomized albino rats: comparison of effects on hematology, serum biochemical parameters, and body weight gain
作者: Rita Ijeoma Udegbunam Henry Nnamdi Okereke Sunday Ositadimma Udegbunam
刊名: Journal of Advanced Veterinary and Animal Research, 2015, Vol.Volume 2 (Issue 3)
来源数据库: Journal of Advanced Veterinary and Animal Research
DOI: 10.5455/javar.2015.b100
关键词: Erythrocytic indicesLaparotomyOpioidTramadol hydrochloride
原始语种摘要: This study was aimed to assess the effects of single and repeated tramadol administration on some hematological and serum biochemical parameters of laparotomized rats. Laparotomized rats (n=18) were randomly divided into three equal groups. Normal saline was administered to the rats of group 1 (control). Tramadol (dosed at 10 mg/kg bwt) was administered singly to the rats of group 2. The same dose of tramadol was administered repeatedly every 12 h up to 72 h to the rats of group 3. On day 3 and 10 post-laparotomy (PSL), blood urea nitrogen, serum creatinine, total serum protein, hematocrit, hemoglobin concentration and red blood cell counts in the rats of group 2 were found to be significantly (P<0.05) higher than those obtained in group 1 and group 3. Mean weights of rats in group 1 and...
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  • tramadol 曲马多
  • biochemical 生物化学的
  • albino 白化体
  • serum 血清
  • repeated 重复的
  • analgesia 痛觉缺失
  • hematocrit 血细胞容量计
  • administration 管理
  • weight 
  • parameters 参数