Mechanism Based Pharmacokinetic Pharmacodynamic Modeling of Vildagliptin as an Add-on to Metformin for Subjects with Type 2 Diabetes
作者: Marziyeh Eftekhari1 and Omid Vahidi
刊名: CMES: Computer Modeling in Engineering & Sciences, 2018, Vol.114 (2), pp.153-171
来源数据库: Tech Science Press
DOI: 10.3970/cmes.2018.114.153
关键词: PharmacokineticsPharmacodynamicsMathematical modelingAnti-diabetic drugsMetforminVildagliptin.
原始语种摘要: Various drugs are used to maintain normoglycemia in subjects with type 2 diabetes mellitus. The combination of the drugs from different classes in one single tablet may enhance the effectiveness of the anti-diabetic drugs. To investigate the impact of combining drugs on the glucose regulation of subjects with type 2 diabetes, we propose a pharmacokinetic/pharmacodynamics (PK/PD) mathematical modeling approach for a combination of metformin and vildagliptin drugs. In the proposed modeling approach, two separate PK models representing oral administration of metformin and vildagliptin for diabetic subjects are interconnected to a PD model comprising a detailed compartmental physiological model representing the regulatory effect of insulin, incretins and glucagon hormones on glucose...
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  • diabetic 糖尿病患者
  • metformin 二甲双胍
  • glucose 葡萄糖
  • glucagon 高血糖素
  • diabetes 糖尿病
  • normoglycemia 血糖量正常
  • drugs 药品
  • insulin 胰岛素
  • administration 管理
  • representing 表示