Monitoring the cellular uptake of Silica-Coated CdSe / ZnS quantum dots by Time-lapse Confocal Laser Scanning Microscopy
作者: Heba ElSayed ElZorkanyHaidan M. El-ShorbagyKhaled Yehia FarrohTareq YoussefSalwa SabetTaher A. Salaheldin
作者单位: 1Nanotechnology and Advanced Materials Central Lab, Agricultural Research Center, Egypt.
2Department of Zoology, Faculty of Science, Cairo University, Egypt.
3Department of Photochemistry Photobiology, National Institute for Laser Enhanced Science (NILES), Cairo University, Egypt.
41-Mostafa Elsayed Center for Nanotechnology Research,British University in Egypt.2-Nanotechnology and Advanced Materials Central Lab, Agricultural Research Center, Egypt.
刊名: Journal of Applied Pharmaceutical Science, 2018, Vol.8 (3), pp.1-8
来源数据库: Open Science Publishers LLP
DOI: 10.7324/JAPS.2018.8301
关键词: Confocal microscopyQuantum dotsSilica coatingHepG2 cellsIn vitro toxicityGreen
原始语种摘要: In this study, we aimed to investigate the efficiency of silica coated CdSe/ZnS nanocrystals (CdSe/ZnS-SiO2 NCs) for imaging purposes. CdSe quantum dots (QDs) were synthesized by organometallic routes and were coated with ZnS shell by injecting solutions of diethylzinc (Zn (Et) 2) and hexamethyldislathiane ((TMS) 2 S) as precursors for zinc and sulfur ions respectively. Then, CdSe/ZnS QDs were rendered water soluble by overcoating with silica using tetraethyl orthosilicate (TEOS) as a silica precursor. QDs were characterized by UV-Vis absorption, emission spectroscopy TEM, XRD and DLS. The biocompatibility of silica-coated QDs (CdSe/ZnS-SiO2) was tested by evaluating mitochondrial activity of liver hepatocellular carcinoma (HepG2) cells exposed to different concentrations of...
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  • overcoating 涂饰
  • silica 硅土
  • orthosilicate 正硅酸盐
  • tetraethyl 四乙基
  • microscopy 显微镜检查
  • luminescence 发光
  • organometallic 有机金属的
  • coated 涂渍的
  • quantum 量子
  • cells 麻风细胞