Response Surface Optimization and In-vitro Evaluation of Sustained Release Topical Insulin Liposomal Spray for Wound Healing
作者: Marwa H. S. DawoudGhada E. YassinDalia M. GhorabNadia M. Morsi
作者单位: 1Assistant Lecturer in October University for Modern Sciences and Arts
2 Associate Prof. at October University for Modern Sciences and Arts
3 Prof. of Pharmaceutics at Faculty of Pharmacy, Cairo University
刊名: Journal of Applied Pharmaceutical Science, 2018, Vol.8 (6), pp.22-29
来源数据库: Open Science Publishers LLP
DOI: 10.7324/JAPS.2018.8604
关键词: InsulinLiposomesSustained releaseTopical sprayFactorial designGreen
原始语种摘要: Chronic wounds are considered a major health care concern, that represent a life-threatening problem worldwide. Insulin has proven its great efficiency as a wound healing agent, especially with diabetic ulcers. However; Insulin suffers degradation at the application site due to proteases, moreover; when wounds are painful the patient fail to apply any remedy frequently. In the present study, Insulin has been formulated as a spray in liposomes, which protects it at the wound area and sustains its release and thus reducing the application frequency, furthermore; the spray reducing the direct contact of the applicator with the skin, thus, reducing the probability of infection. Full-factorial design has been applied in the preparation optimization of liposomes, where the effects of the...
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  • cholesterol 胆甾醇
  • spray 喷雾
  • diabetic 糖尿病患者
  • applicator 敷料器
  • Release 免除释放机构
  • proven 证明
  • release 释放
  • reducing 还原
  • sonication 声裂法
  • degradation 减嚣夷酌