Heteromeric amino acid transporters. In search of the molecular bases of transport cycle mechanisms <sup>1</sup>
作者: Manuel PalacínEkaitz Errasti-MurugarrenAlbert Rosell
作者单位: 1Institute for Research in Biomedicine Barcelona (IRB), 08028 Barcelona, Spain
2The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain
3Spanish Biomedical Research Center in Rare Diseases (CIBERER), 46010 Valencia, Spain
4Department of Biochemistry and Molecular Biology, Facultat de Biologia, University of Barcelona, 08028 Barcelona, Spain
刊名: Biochemical Society Transactions, 2016, Vol.44 (3), pp.745-752
来源数据库: Portland Press Limited
DOI: 10.1042/BST20150294
关键词: Amino acid transportersHeterodimerHeteromeric amino acid transporter (HAT)ModellingStructureTransport mechanism
原始语种摘要: Heteromeric amino acid transporters (HATs) are relevant targets for structural studies. On the one hand, HATs are involved in inherited and acquired human pathologies. On the other hand, these molecules are the only known examples of solute transporters composed of two subunits (heavy and light) linked by a disulfide bridge. Unfortunately, structural knowledge of HATs is scarce and limited to the atomic structure of the ectodomain of a heavy subunit (human 4F2hc-ED) and distant prokaryotic homologues of the light subunits that share a LeuT-fold. Recent data on human 4F2hc/LAT2 at nanometer resolution revealed 4F2hc-ED positioned on top of the external loops of the light subunit LAT2. Improved resolution of the structure of HATs, combined with conformational studies, is essential to...
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影响因子:2.587 (2012)

  • transport 输运
  • amino 氨基
  • prokaryotic 原核生物的
  • bases 脱氧核糖核酸基盐
  • search 搜索
  • functional 功能的
  • disulfide 二硫化物
  • evaluate 求...的值
  • light 
  • structural 构造